Delivery strategies for novel vaccine formulations.

TitleDelivery strategies for novel vaccine formulations.
Publication TypeJournal Article
Year of Publication2012
AuthorsTrovato M, Krebs SJ, Haigwood NL, De Berardinis P
JournalWorld journal of virology
Volume1
Issue1
Pagination4-10
Date Published2012 Feb 12
Abstract

A major challenge in vaccine design is to identify antigen presentation and delivery systems capable of rapidly stimulating both the humoral and cellular components of the immune system to elicit a strong and sustained immunity against different viral isolates. Approaches to achieve this end involve live attenuated and inactivated virions, viral vectors, DNA, and protein subunits. This review reports the state of current antigen delivery, and focuses on two innovative systems recently established at our labs. These systems are the filamentous bacteriophage fd and an icosahedral scaffold formed by the acyltransferase component (E2 protein) of the pyruvate dehydrogenase complex of Bacillus stearothermophilus.

DOI10.1002/jbmr.2057
Alternate JournalWorld J Virol