The DEAD/DEAH box helicase, DDX11, is essential for the survival of advanced melanomas.

TitleThe DEAD/DEAH box helicase, DDX11, is essential for the survival of advanced melanomas.
Publication TypeJournal Article
Year of Publication2012
AuthorsBhattacharya C, Wang X, Becker D
JournalMolecular cancer
Volume11
Pagination82
Date Published2012
Abstract

Despite continuous efforts to identify genes that are pivotal regulators of advanced melanoma and closely related to it, to determine which of these genes have to be blocked in their function to keep this highly aggressive disease in check, it is far from clear which molecular pathway(s) and specific genes therein, is the Achilles' heel of primary and metastatic melanoma. In this report, we present data, which document that the DEAD-box helicase DDX11, which is required for sister chromatid cohesion, is a crucial gatekeeper for melanoma cell survival.

DOI10.1002/mus.23848
Alternate JournalMol. Cancer