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DDQ-induced dehydrogenation of heterocycles for C-C double bond formation: synthesis of 2-thiazoles and 2-oxazoles.
|Title||DDQ-induced dehydrogenation of heterocycles for C-C double bond formation: synthesis of 2-thiazoles and 2-oxazoles.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Li X, Li C, Yin B, Li C, Liu P, Li J, Shi Z|
|Journal||Chemistry, an Asian journal|
|Date Published||2013 Jul|
Strong as an Ox: 2-Thiazoles and 2-oxazoles are formed by oxidation of 2-thiazolines and 2-oxazolines without requiring substituents at the C4 and C5 positions. DDQ plays an important role as the oxidant in this transformation and metal is unnecessary. This general procedure shows good functional group tolerance and provides a wide variety of 2-thiazoles and 2-oxazoles in moderate to excellent yields.
|Alternate Journal||Chem Asian J|