DDQ-induced dehydrogenation of heterocycles for C-C double bond formation: synthesis of 2-thiazoles and 2-oxazoles.

TitleDDQ-induced dehydrogenation of heterocycles for C-C double bond formation: synthesis of 2-thiazoles and 2-oxazoles.
Publication TypeJournal Article
Year of Publication2013
AuthorsLi X, Li C, Yin B, Li C, Liu P, Li J, Shi Z
JournalChemistry, an Asian journal
Volume8
Issue7
Pagination1408-11
Date Published2013 Jul
Abstract

Strong as an Ox: 2-Thiazoles and 2-oxazoles are formed by oxidation of 2-thiazolines and 2-oxazolines without requiring substituents at the C4 and C5 positions. DDQ plays an important role as the oxidant in this transformation and metal is unnecessary. This general procedure shows good functional group tolerance and provides a wide variety of 2-thiazoles and 2-oxazoles in moderate to excellent yields.

DOI10.1371/journal.pone.0062610
Alternate JournalChem Asian J