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Correlation between apoptosis and TGF-β1 expression in the mucosal epithelium of rat small intestine in a cold stress state.
|Title||Correlation between apoptosis and TGF-β1 expression in the mucosal epithelium of rat small intestine in a cold stress state.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Li Y, Tian D|
|Journal||Experimental and therapeutic medicine|
|Date Published||2013 May|
The aim of this study was to investigate the correlation between the expression of transforming growth factor-β1 (TGF-β1) in the mucosal tissue of rat small intestine and the apoptosis of epithelial cells in the small intestine in a cold-restraint stress state. Immunohistochemistry was used to detect the expression of TGF-β1. Terminal deoxynucleotidyl transferase deoxyuridine triphosphate (dUTP) nick end labeling (TUNEL) and DNA agarose gel electrophoresis were used to detect apoptosis. After 8 and 12 h of cold-restraint stress, the positive expression rate of TGF-β1 in the rat small intestine epithelial tissue was 59.09 and 54.16%, respectively. The apoptotic index (AI) of the rat small intestine epithelial cells was 25.69±8.09 and 19.65±6.61%, respectively. The positive expression rate of TGF-β1 in the epithelial tissue of the rat small intestine was positively correlated with the AI of the epithelial cells (r=0.980, P<0.05). The epithelial cells of the rat small intestine exhibited apoptosis under cold-restraint stress. TGF-β1 is one of the key factors that induces apoptosis of the epithelial cells of the rat small intestine.
|Alternate Journal||Exp Ther Med|