Copper-catalyzed annulation of amidines for quinazoline synthesis.

TitleCopper-catalyzed annulation of amidines for quinazoline synthesis.
Publication TypeJournal Article
Year of Publication2013
AuthorsLv Y, Li Y, Xiong T, Pu W, Zhang H, Sun K, Liu Q, Zhang Q
JournalChemical communications (Cambridge, England)
Date Published2013 Jul 21

An efficient Cu-catalyzed synthesis of quinazolines via the C-N bond formation reactions between N-H bonds of amidines and C(sp(3))-H bonds adjacent to sulfur or nitrogen atoms in the commonly used solvents, such as DMSO, DMF, DMA, NMP or TMEDA, followed by intramolecular C-C bond formation reactions was developed for the first time.

Alternate JournalChem. Commun. (Camb.)