News & Updates
Search Research Content
Resource Finder at Kennedy Krieger Institute
A free resource that provides access to information and support for individuals and families living with developmental disabilities.
Conjugated polyelectrolytes with aggregation-enhanced emission characteristics: synthesis and their biological applications.
|Title||Conjugated polyelectrolytes with aggregation-enhanced emission characteristics: synthesis and their biological applications.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Hu R, Ye R, Lam JWY, Li M, Leung CWT, Tang BZ|
|Journal||Chemistry, an Asian journal|
|Date Published||2013 Oct|
Conjugated polyelectrolytes are promising candidates for the construction of fluorescent bioprobes. In this study, a series of water-soluble fluorescent polyelectrolytes have been designed and synthesized by means of the quaternization of their tetraphenylethene-containing polyyne precursors. The polyynes can be facilely prepared through Hay-Glaser polycoupling in high yields (up to 99%) with high molecular weights (up to 38,900). All the polymers exhibit a phenomenon of aggregation-induced or -enhanced emission. The fluorimetric titrations of biomolecules such as heparin, calf thymus DNA, RNA, bovine serum albumin, and human serum albumin to buffer solutions of the polyelectrolytes suggest that they are promising fluorescent bioprobes with high sensitivity and fast response. The emission intensity of the polyelectrolytes is enhanced by up to sevenfold upon binding with biomolecules through electrostatic and hydrophobic cooperative interactions. The polyelectrolytes can also serve as fluorescent visualizers for intracellular imaging with good biocompatibility and low autofluorescence interference.
|Alternate Journal||Chem Asian J|