Concise review: Preclinical studies on human cell-based therapy in rodent ischemic stroke models: where are we now after a decade?

TitleConcise review: Preclinical studies on human cell-based therapy in rodent ischemic stroke models: where are we now after a decade?
Publication TypeJournal Article
Year of Publication2013
AuthorsLeong WK, Lewis MD, Koblar SA
JournalStem cells (Dayton, Ohio)
Volume31
Issue6
Pagination1040-3
Date Published2013 Jun
Abstract

Stroke, a debilitating brain insult, afflicts millions of individuals globally each year. In the last decade, researchers have investigated cell-based therapy as an alternative strategy to improve neurological outcome following stroke. This concise review critically examines preclinical reports using human adult and fetal stem/progenitor cells in rodent models of ischemic stroke. As we enter the second decade of study, we should aim to optimize our collective likelihood to translational success for stroke victims worldwide. We advocate international consensus recommendations be developed for future preclinical research.

DOI10.1111/ans.12135
Alternate JournalStem Cells