Combined treatment for cutaneous Rosai-Dorfman disease: a report of 2 cases.

TitleCombined treatment for cutaneous Rosai-Dorfman disease: a report of 2 cases.
Publication TypeJournal Article
Year of Publication2013
AuthorsXia J-X, Jin X-H, Mou Y, Li X, Yu K, Zhu W-J, Li F-Q
JournalInternational journal of clinical and experimental medicine
Volume6
Issue9
Pagination822-7
Date Published2013
Abstract

We report 2 cases of cutaneous Rosai-Dorfman disease (CRDD). One was a 46-year-old Chinese woman who presented with a 10-year history of multiple papules and nodules on the left cheek. Another one was a 57-year-old Chinese woman who presented with a 7-month history of erythematous pruritic plaque on the Dorsum nasi. Their lesions consisted of proliferative large histiocytes occasionally showing emperipolesis. Immunohistochemistry showed these histiocytes were positive for CD68 and S-100, but negative for CD1a. A diagnosis of CRDD was made. Their lesions were improved after intralesional treatment with Compound Betamethasone, interferon and acitretin. To our knowledge, we for the first time reported the application of intralesional Compound Betamethasone and Lidocaine, intramuscular injection of interferon, and oral acitretin in the treatment of CRDD, and favorable outcome was achieved without recurrence over a 1-year follow-up period.

DOI10.1016/j.nicl.2013.08.006
Alternate JournalInt J Clin Exp Med