Chronic scopolamine-injection-induced cognitive deficit on reward-directed instrumental learning in rat is associated with CREB signaling activity in the cerebral cortex and dorsal hippocampus.

TitleChronic scopolamine-injection-induced cognitive deficit on reward-directed instrumental learning in rat is associated with CREB signaling activity in the cerebral cortex and dorsal hippocampus.
Publication TypeJournal Article
Year of Publication2013
AuthorsShi Z, Chen L, Li S, Chen S, Sun X, Sun L, Li Y, Zeng J, He Y, Liu X
JournalPsychopharmacology
Volume230
Issue2
Pagination245-60
Date Published2013 Nov
Abstract

Scopolamine, a nonselective muscarinic receptor antagonist, has been used in experimental animal models of dementia. It has been demonstrated to disrupt performances in a battery of behavioral tests. However, no attempt has been made to determine how scopolamine-treated animals would respond to a series of reward-directed instrumental learning (RDIL) tasks.

DOI10.1155/2013/195692
Alternate JournalPsychopharmacology (Berl.)