Chemoselective oxidative C(CO)-C(methyl) bond cleavage of methyl ketones to aldehydes catalyzed by CuI with molecular oxygen.

TitleChemoselective oxidative C(CO)-C(methyl) bond cleavage of methyl ketones to aldehydes catalyzed by CuI with molecular oxygen.
Publication TypeJournal Article
Year of Publication2013
AuthorsZhang L, Bi X, Guan X, Li X, Liu Q, Barry B-D, Liao P
JournalAngewandte Chemie (International ed. in English)
Volume52
Issue43
Pagination11303-7
Date Published2013 Oct 18
Abstract

Aldehyde Termination: A novel copper-catalyzed transformation from methyl ketones into aldehydes has been accomplished. This method is applicable to a wide range of aromatic and aliphatic methyl ketones and chemoselectively produces aldehydes, accompanied by the release of hydrogen (H2 ) and carbon dioxide (CO2 ) as by-products.

DOI10.1002/anie.201305010
Alternate JournalAngew. Chem. Int. Ed. Engl.