Chemokine (C-C motif) ligand 20, a potential biomarker for Graves' disease, is regulated by osteopontin.

TitleChemokine (C-C motif) ligand 20, a potential biomarker for Graves' disease, is regulated by osteopontin.
Publication TypeJournal Article
Year of Publication2013
AuthorsLi X, Qi Y, Ma X, Huang F, Guo H, Jiang X, Hong J, Lin D, Cui B, Ning G, Xu L, Wang S
JournalPloS one
Volume8
Issue5
Paginatione64277
Date Published2013
Abstract

Graves' disease (GD) is a common autoimmune disease involving the thyroid gland. The altered balance of pro- and anti-inflammatory cytokines plays an important role in the pathogenesis of GD. Chemokine (C-C motif) ligand 20 (CCL20) is important for interleukin-17 (IL-17) signal activation and a potent chemoattractant for Th17 cells. Meanwhile, Osteopontin (OPN), a broadly expressed pleiotropic cytokine, has been implicated in GD through inducing Th1-involved response to enhance the production of proinflammatory cytokines and chemokines, but little is known about the role of OPN in regulating CCL20 and IL-17 signaling.

DOI10.3969/j.issn.1672-7347.2013.06.013
Alternate JournalPLoS ONE