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Chemokine (C-C motif) ligand 20, a potential biomarker for Graves' disease, is regulated by osteopontin.
|Title||Chemokine (C-C motif) ligand 20, a potential biomarker for Graves' disease, is regulated by osteopontin.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Li X, Qi Y, Ma X, Huang F, Guo H, Jiang X, Hong J, Lin D, Cui B, Ning G, Xu L, Wang S|
Graves' disease (GD) is a common autoimmune disease involving the thyroid gland. The altered balance of pro- and anti-inflammatory cytokines plays an important role in the pathogenesis of GD. Chemokine (C-C motif) ligand 20 (CCL20) is important for interleukin-17 (IL-17) signal activation and a potent chemoattractant for Th17 cells. Meanwhile, Osteopontin (OPN), a broadly expressed pleiotropic cytokine, has been implicated in GD through inducing Th1-involved response to enhance the production of proinflammatory cytokines and chemokines, but little is known about the role of OPN in regulating CCL20 and IL-17 signaling.
|Alternate Journal||PLoS ONE|