Chemical constituents from the roots and stems of Erycibe obtusifolia and their in vitro antiviral activity.

TitleChemical constituents from the roots and stems of Erycibe obtusifolia and their in vitro antiviral activity.
Publication TypeJournal Article
Year of Publication2013
AuthorsFan L, Wang Y, Liang N, Huang X-J, Li M-M, Fan C-L, Wu Z-L, Li Y-L, Ye W-C
JournalPlanta medica
Volume79
Issue16
Pagination1558-64
Date Published2013 Nov
Abstract

Three new quinic acid derivatives, 4-O-caffeoyl-3-O-sinapoylquinic acid methyl ester (1), 5-O-caffeoyl-4-O-syringoylquinic acid methyl ester (2), and 4-O-caffeoyl-3-O-syringoylquinic acid methyl ester (3), as well as four new coumarin glycosides, 7-O-(3-O-sinapoyl-β-D-glucopyranosyl)-6-methoxycoumarin (12), 7-O-(6-O-sinapoyl-β-D-glucopyranosyl)-6-methoxycoumarin (13), 7-O-(2-O-sinapoyl-β-D-glucopyranosyl)-6-methoxycoumarin (14), and 7-O-(6-O-syringoyl-β-D-glucopyranosyl)-6-methoxycoumarin (15), together with eight known compounds (4-11) were isolated from the roots and stems of Erycibe obtusifolia. Their structures were elucidated on the basis of spectroscopic analysis and chemical evidence. All the compounds were screened for their in vitro antiviral activity against respiratory syncytial virus with a cytopathic effect reduction assay. Among them, the di-O-caffeoyl quinates 8-11 displayed a potent in vitro anti-respiratory syncytial virus effect.

DOI10.1371/journal.pone.0076036
Alternate JournalPlanta Med.