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CHD@ZJU: a knowledgebase providing network-based research platform on coronary heart disease.
|Title||CHD@ZJU: a knowledgebase providing network-based research platform on coronary heart disease.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Wu L, Li X, Yang J, Liu Y, Fan X, Cheng Y|
|Journal||Database : the journal of biological databases and curation|
Coronary heart disease (CHD), the leading cause of global morbidity and mortality in adults, has been reported to be associated with hundreds of genes. A comprehensive understanding of the CHD-related genes and their corresponding interactions is essential to advance the translational research on CHD. Accordingly, we construct this knowledgebase, CHD@ZJU, which records CHD-related information (genes, pathways, drugs and references) collected from different resources and through text-mining method followed by manual confirmation. In current release, CHD@ZJU contains 660 CHD-related genes, 45 common pathways and 1405 drugs accompanied with >8000 supporting references. Almost half of the genes collected in CHD@ZJU were novel to other publicly available CHD databases. Additionally, CHD@ZJU incorporated the protein-protein interactions to investigate the cross-talk within the pathways from a multi-layer network view. These functions offered by CHD@ZJU would allow researchers to dissect the molecular mechanism of CHD in a systematic manner and therefore facilitate the research on CHD-related multi-target therapeutic discovery. Database URL: http://tcm.zju.edu.cn/chd/
|Alternate Journal||Database (Oxford)|