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The CCR6/CCL20 axis mediates Th17 cell migration to the ocular surface in dry eye disease.
|Title||The CCR6/CCL20 axis mediates Th17 cell migration to the ocular surface in dry eye disease.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Dohlman TH, Chauhan SK, Kodati S, Hua J, Chen Y, Omoto M, Sadrai Z, Dana R|
|Journal||Investigative ophthalmology & visual science|
|Date Published||2013 Jun|
Th17 cells are believed to be the primary effector cells in the pathogenesis of dry eye disease (DED). However, the mechanisms by which Th17 cells migrate from the lymphoid tissues to the ocular surface are unknown. The purpose of this study was to investigate the role of the C-C chemokine receptor 6/C-C chemokine ligand 20 (CCR6/CCL20) chemokine axis in mediating Th17 cell migration in DED.
|Alternate Journal||Invest. Ophthalmol. Vis. Sci.|