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Catalytic enantioselective synthesis of naturally occurring butenolides via hetero-allylic alkylation and ring closing metathesis.
| Title | Catalytic enantioselective synthesis of naturally occurring butenolides via hetero-allylic alkylation and ring closing metathesis. |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Mao B, Geurts K, Fañanás-Mastral M, van Zijl AW, Fletcher SP, Minnaard AJ, Feringa BL |
| Journal | Organic letters |
| Volume | 13 |
| Issue | 5 |
| Pagination | 948-51 |
| Date Published | 2011 Mar 4 |
| Abstract | An efficient catalytic asymmetric synthesis of chiral γ-butenolides was developed based on the hetero-allylic asymmetric alkylation (h-AAA) in combination with ring closing metathesis (RCM). The synthetic potential of the h-AAA-RCM protocol was illustrated with the facile synthesis of (-)-whiskey lactone, (-)-cognac lactone, (-)-nephrosteranic acid, and (-)-roccellaric acid. |
| DOI | 10.1002/mrm.24161 |
| Alternate Journal | Org. Lett. |
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