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Breaking the conservation of guanine residues in the catalytic loop of 10-23 DNAzyme by position-specific nucleobase modifications for rate enhancement.
|Title||Breaking the conservation of guanine residues in the catalytic loop of 10-23 DNAzyme by position-specific nucleobase modifications for rate enhancement.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Liu Y, Li Z, Liu G, Wang Q, Chen W, Zhang D, Cheng M, Zheng Z, Liu K, He J|
|Journal||Chemical communications (Cambridge, England)|
|Date Published||2013 Jun 4|
10-23 DNAzyme has been used as a very good model for exploring the potential of functional nucleic acids. Its 15-mer catalytic core has been demonstrated to be the optimized in vitro selection result. However, with the introduction of protein-like functional groups through 2'-deoxyguanosine analogues, its two highly conserved guanine residues (G2 and G14) can be modified for more efficient 10-23 DNAzyme analogues. This result implies that chemical modifications of functional nucleic acids with well-designed nucleoside analogues of each canonical residue could be used as the first step in the efforts toward more powerful functions of nucleic acids.
|Alternate Journal||Chem. Commun. (Camb.)|