Both ERK/MAPK and TGF-Beta/Smad signaling pathways play a role in the kidney fibrosis of diabetic mice accelerated by blood glucose fluctuation.

TitleBoth ERK/MAPK and TGF-Beta/Smad signaling pathways play a role in the kidney fibrosis of diabetic mice accelerated by blood glucose fluctuation.
Publication TypeJournal Article
Year of Publication2013
AuthorsCheng X, Gao W, Dang Y, Liu X, Li Y, Peng X, Ye X
JournalJournal of diabetes research
Volume2013
Pagination463740
Date Published2013
Abstract

The notion that diabetic nephropathy is the leading cause of renal fibrosis prompted us to investigate the effects of blood glucose fluctuation (BGF) under high glucose condition on kidney in the mice.

DOI10.1155/2013/972347
Alternate JournalJ Diabetes Res