Blockade of the formation of insoluble ubiquitinated protein aggregates by EGCG3"me in the alloxan-induced diabetic kidney.

TitleBlockade of the formation of insoluble ubiquitinated protein aggregates by EGCG3"me in the alloxan-induced diabetic kidney.
Publication TypeJournal Article
Year of Publication2013
AuthorsCai S, Zhong Y, Li Y, Huang J, Zhang J, Luo G, Liu Z
JournalPloS one
Volume8
Issue9
Paginatione75687
Date Published2013
Abstract

Renal accumulation of reactive carbonyl compounds (RCCs) has been linked to the progression of diabetic nephropathy. We previously demonstrated that carbonyl stress induces the formation of amino-carbonyl cross-links and sharply increases the content of β-sheet-rich structures, which is the seed of insoluble aggregates formation, and tea catechin (-)-epigallocatechin 3-gallate (EGCG) can reverse this process in vitro and in vivo. In this study, methylated derivative (-)-epigallocatechin-3-O-(3-O-methyl)-gallate (EGCG3"Me) was hypothesized to neutralize carbonyl stress mediating the formation of insoluble ubiquitinated protein (IUP) aggregates, and reduce the early development of diabetic nephropathy.

DOI10.4103/2156-7514.119019
Alternate JournalPLoS ONE