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Blockade of the formation of insoluble ubiquitinated protein aggregates by EGCG3"me in the alloxan-induced diabetic kidney.
|Title||Blockade of the formation of insoluble ubiquitinated protein aggregates by EGCG3"me in the alloxan-induced diabetic kidney.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Cai S, Zhong Y, Li Y, Huang J, Zhang J, Luo G, Liu Z|
Renal accumulation of reactive carbonyl compounds (RCCs) has been linked to the progression of diabetic nephropathy. We previously demonstrated that carbonyl stress induces the formation of amino-carbonyl cross-links and sharply increases the content of β-sheet-rich structures, which is the seed of insoluble aggregates formation, and tea catechin (-)-epigallocatechin 3-gallate (EGCG) can reverse this process in vitro and in vivo. In this study, methylated derivative (-)-epigallocatechin-3-O-(3-O-methyl)-gallate (EGCG3"Me) was hypothesized to neutralize carbonyl stress mediating the formation of insoluble ubiquitinated protein (IUP) aggregates, and reduce the early development of diabetic nephropathy.
|Alternate Journal||PLoS ONE|