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Bioactive lignans from the leaves and stems of Schisandra wilsoniana.
|Title||Bioactive lignans from the leaves and stems of Schisandra wilsoniana.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Yang G-Y, Wang R-R, Gao Z-H, Lia Y-K, Yang L-M, Li X-N, Shang S-Z, Zheng Y-T, Xiao W-L, Sun H-D|
|Journal||Natural product communications|
|Date Published||2013 Apr|
Three new dibenzocyclooctadiene lignans, marlignans M-O (1-3), together two known ones, were isolated from the leaves and stems of Schisandra wilsoniana. The structures of 1-3 were elucidated by spectroscopic methods, including extensive 1D- and 2D-NMR techniques. Compound 2 showed anti-HIV-1 activity with an EC50 value of 5.82 microg/mL and a therapeutic index (TI) of more than 12.8. Compound 3 showed obvious bioactivity in inhibiting Epstein-Barr virus early antigen (EBV-EA) activation.
|Alternate Journal||Nat Prod Commun|