Bioactive lignans from the leaves and stems of Schisandra wilsoniana.

TitleBioactive lignans from the leaves and stems of Schisandra wilsoniana.
Publication TypeJournal Article
Year of Publication2013
AuthorsYang G-Y, Wang R-R, Gao Z-H, Lia Y-K, Yang L-M, Li X-N, Shang S-Z, Zheng Y-T, Xiao W-L, Sun H-D
JournalNatural product communications
Volume8
Issue4
Pagination467-70
Date Published2013 Apr
Abstract

Three new dibenzocyclooctadiene lignans, marlignans M-O (1-3), together two known ones, were isolated from the leaves and stems of Schisandra wilsoniana. The structures of 1-3 were elucidated by spectroscopic methods, including extensive 1D- and 2D-NMR techniques. Compound 2 showed anti-HIV-1 activity with an EC50 value of 5.82 microg/mL and a therapeutic index (TI) of more than 12.8. Compound 3 showed obvious bioactivity in inhibiting Epstein-Barr virus early antigen (EBV-EA) activation.

DOI10.7860/JCDR/2013/5829.3091
Alternate JournalNat Prod Commun