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Base-catalyzed cyclization of N-sulfonyl propargylamides to sulfonylmethyl-substituted oxazoles via sulfonyl migration.
|Title||Base-catalyzed cyclization of N-sulfonyl propargylamides to sulfonylmethyl-substituted oxazoles via sulfonyl migration.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Yu X, Xin X, Wan B, Li X|
|Journal||The Journal of organic chemistry|
|Date Published||2013 May 17|
The reaction of N-sulfonyl propargylamides in the presence of a base catalyst selectively affords 5-sulfonylmethyl oxazoles via 1,4-sulfonyl migration. Allenes have been established as the key intermediates. Experimental evidence has been provided to support a two-step mechanism in the cyclization.
|Alternate Journal||J. Org. Chem.|