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Bacterial subversion of host innate immune pathways.
|Title||Bacterial subversion of host innate immune pathways.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Baxt LA, Garza-Mayers AC, Goldberg MB|
|Journal||Science (New York, N.Y.)|
|Date Published||2013 May 10|
The pathogenesis of infection is a continuously evolving battle between the human host and the infecting microbe. The past decade has brought a burst of insights into the molecular mechanisms of innate immune responses to bacterial pathogens. In parallel, multiple specific mechanisms by which microorganisms subvert these host responses have been uncovered. This Review highlights recently characterized mechanisms by which bacterial pathogens avoid killing by innate host responses, including autophagy pathways and a proinflammatory cytokine transcriptional response, and by the manipulation of vesicular trafficking to avoid the toxicity of lysosomal enzymes.