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Asymmetric allylic alkylation in combination with ring-closing metathesis for the preparation of chiral N-heterocycles.
|Title||Asymmetric allylic alkylation in combination with ring-closing metathesis for the preparation of chiral N-heterocycles.|
|Publication Type||Journal Article|
|Year of Publication||2010|
|Authors||Teichert JF, Zhang S, van Zijl AW, Slaa JW, Minnaard AJ, Feringa BL|
|Date Published||2010 Oct 15|
Asymmetric copper-catalyzed allylic substitution with methylmagnesium bromide is employed in combination with ring-closing olefin metathesis or ene-yne metathesis to achieve the synthesis of chiral, unsaturated nitrogen heterocycles. The resulting six- to eight-membered chiral heterocycles are accessible in high yields and with excellent enantioselectivities.
|Alternate Journal||Org. Lett.|