Astaxanthin protects ARPE-19 cells from oxidative stress via upregulation of Nrf2-regulated phase II enzymes through activation of PI3K/Akt.

TitleAstaxanthin protects ARPE-19 cells from oxidative stress via upregulation of Nrf2-regulated phase II enzymes through activation of PI3K/Akt.
Publication TypeJournal Article
Year of Publication2013
AuthorsLi Z, Dong X, Liu H, Chen X, Shi H, Fan Y, Hou D, Zhang X
JournalMolecular vision
Volume19
Pagination1656-66
Date Published2013
Abstract

Oxidative stress on retinal pigment epithelial (RPE) cells is thought to play a crucial role in the development and progression of age-related macular degeneration. Astaxanthin (AST) is a carotenoid that shows significant antioxidant properties. This study was designed to investigate the protective effect of AST on ARPE-19 cells against oxidative stress and the possible underlying mechanism.

DOI10.3348/kjr.2013.14.4.581
Alternate JournalMol. Vis.