Association of LEP G2548A and LEPR Q223R Polymorphisms with Cancer Susceptibility: Evidence from a Meta-Analysis.

TitleAssociation of LEP G2548A and LEPR Q223R Polymorphisms with Cancer Susceptibility: Evidence from a Meta-Analysis.
Publication TypeJournal Article
Year of Publication2013
AuthorsHe J, Xi B, Ruiter R, Shi T-Y, Zhu M-L, Wang M-Y, Li Q-X, Zhou X-Y, Qiu L-X, Wei Q-Y
JournalPloS one
Volume8
Issue10
Paginatione75135
Date Published2013
Abstract

Numerous epidemiological studies have examined associations of genetic variations in LEP (G2548A, -2548 nucleotide upstream of the ATG start site) and LEPR (Q223R, nonsynonymous SNP in exon 6) with cancer susceptibility; however, the findings are inconsistent. Therefore, we performed a meta-analysis to comprehensively evaluate such associations.

DOI10.1371/journal.pone.0078109
Alternate JournalPLoS ONE