Association of follicle-stimulating hormone receptor polymorphisms with ovarian response in Chinese women: a prospective clinical study.

TitleAssociation of follicle-stimulating hormone receptor polymorphisms with ovarian response in Chinese women: a prospective clinical study.
Publication TypeJournal Article
Year of Publication2013
AuthorsYan Y, Gong Z, Zhang L, Li Y, Li X, Zhu L, Sun L
JournalPloS one
Volume8
Issue10
Paginatione78138
Date Published2013
Abstract

Follicular stimulating hormone (FSH) is a glycoprotein and widely used for the treatment of infertility; FSH action is mediated by FSH receptor (FSHR), SNPs of which determine the ovarian response. Two polymorphisms of the FSHR gene were identified, which caused a change of threonine (T) to alanine (A) at position 307 and asparagine (N) to serine(S) at position 680. Both polymorphic sites give rise to three discrete variants of the FSHR: TT, TA, and AA for position 307; NN, NS, and SS for position 680.

DOI10.1371/journal.pone.0078451
Alternate JournalPLoS ONE