Association of dopamine D2 receptor and leptin receptor genes with clinically severe obesity.

TitleAssociation of dopamine D2 receptor and leptin receptor genes with clinically severe obesity.
Publication TypeJournal Article
Year of Publication2013
AuthorsCarpenter CL, Wong AM, Li Z, Noble EP, Heber D
JournalObesity (Silver Spring, Md.)
Volume21
Issue9
PaginationE467-73
Date Published2013 Sep
Abstract

The brain reward circuits that promote drug abuse may also be involved in pleasure seeking behavior and food cravings observed in severely obese subjects. Drug addiction polymorphisms such as the TaqI A1 allele of the dopamine D2 receptor (DRD2) are associated with cocaine, alcohol, and opioid use, but few studies have linked DRD2 to food craving. Other genes such as the leptin receptor gene (LEPR) and mu-opioid receptor gene (OPRM1) that affect appetite and pleasure centers in the brain may also influence food addiction and obesity. The three genes together may function synergistically.

DOI10.1155/2013/405284
Alternate JournalObesity (Silver Spring)