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Association of BRCA1/2 mutations with FMR1 genotypes: effects on menarcheal and menopausal age.
|Title||Association of BRCA1/2 mutations with FMR1 genotypes: effects on menarcheal and menopausal age.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Tea M-KM, Weghofer A, Wagner K, Singer CF|
|Date Published||2013 Jun|
Female BRCA (breast cancer gene)-1 and BRCA-2 mutations are significantly associated with risk of developing breast and ovarian cancers, in turn, associated with female infertility. BRCA-1 mutations have also been associated with occult primary ovarian insufficiency (OPOI), as have different mutations of the FMR1 gene. We, therefore, hypothesized that FMR1 genotypes may be associated with menarcheal and menopausal ages of BRCA mutation carriers.