Association of BRCA1/2 mutations with FMR1 genotypes: effects on menarcheal and menopausal age.

TitleAssociation of BRCA1/2 mutations with FMR1 genotypes: effects on menarcheal and menopausal age.
Publication TypeJournal Article
Year of Publication2013
AuthorsTea M-KM, Weghofer A, Wagner K, Singer CF
JournalMaturitas
Volume75
Issue2
Pagination148-51
Date Published2013 Jun
Abstract

Female BRCA (breast cancer gene)-1 and BRCA-2 mutations are significantly associated with risk of developing breast and ovarian cancers, in turn, associated with female infertility. BRCA-1 mutations have also been associated with occult primary ovarian insufficiency (OPOI), as have different mutations of the FMR1 gene. We, therefore, hypothesized that FMR1 genotypes may be associated with menarcheal and menopausal ages of BRCA mutation carriers.

DOI10.1016/j.maturitas.2013.03.002
Alternate JournalMaturitas