Association between RASSF1A Promoter Methylation and Ovarian Cancer: A Meta-Analysis.

TitleAssociation between RASSF1A Promoter Methylation and Ovarian Cancer: A Meta-Analysis.
Publication TypeJournal Article
Year of Publication2013
AuthorsShi H, Li Y, Wang X, Lu C, Yang L, Gu C, Xiong J, Huang Y, Wang S, Lu M
JournalPloS one
Volume8
Issue10
Paginatione76787
Date Published2013
Abstract

The RAS association domain family protein 1a gene (RASSF1A) is one of the tumor suppressor genes (TSG). Inactivation of RASSF1A is critical to the pathogenesis of cancer. Aberrant TSG methylation was considered an important epigenetic silencing mechanism in the progression of ovarian cancer. A number of studies have discussed association between RASSF1A promoter methylation and ovarian cancer. However, they were mostly based on a small number of samples and showed inconsist results, Therefore, we conducted a meta-analysis to better identify the association.

DOI10.1039/c3an01437a
Alternate JournalPLoS ONE