Association between IL-4 -589C>T polymorphism and colorectal cancer risk.

TitleAssociation between IL-4 -589C>T polymorphism and colorectal cancer risk.
Publication TypeJournal Article
Year of Publication2013
AuthorsLi Q, Wang Q, Xu X, Ren S, Wang L
JournalTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
Date Published2013 Nov 12

In order to make a comprehensive assessment of the potential association between interleukin-4 (IL-4) -589C>T and colorectal cancer (CRC) susceptibility, we conducted a meta-analysis of six epidemiological studies, which included 1,317 CRC patients and 1,659 controls. The data showed that IL-4 -589C>T was not associated with increased CRC risk in the overall population. In the subgroup analysis of IL-4 -589C>T, the results did not change when the analyses were restricted to race. Based on this meta-analysis, we conclude that IL-4 -589C>T may be not a risk factor for CRC development. Further research is needed to assess possible gene-gene or gene-environment-lifestyle interactions on CRC.

Alternate JournalTumour Biol.