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Association between IL-4 -589C>T polymorphism and colorectal cancer risk.
|Title||Association between IL-4 -589C>T polymorphism and colorectal cancer risk.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Li Q, Wang Q, Xu X, Ren S, Wang L|
|Journal||Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine|
|Date Published||2013 Nov 12|
In order to make a comprehensive assessment of the potential association between interleukin-4 (IL-4) -589C>T and colorectal cancer (CRC) susceptibility, we conducted a meta-analysis of six epidemiological studies, which included 1,317 CRC patients and 1,659 controls. The data showed that IL-4 -589C>T was not associated with increased CRC risk in the overall population. In the subgroup analysis of IL-4 -589C>T, the results did not change when the analyses were restricted to race. Based on this meta-analysis, we conclude that IL-4 -589C>T may be not a risk factor for CRC development. Further research is needed to assess possible gene-gene or gene-environment-lifestyle interactions on CRC.
|Alternate Journal||Tumour Biol.|