Assessment of MRI parameters as imaging biomarkers for radiation necrosis in the rat brain.

TitleAssessment of MRI parameters as imaging biomarkers for radiation necrosis in the rat brain.
Publication TypeJournal Article
Year of Publication2012
AuthorsWang S, Tryggestad E, Zhou T, Armour M, Wen Z, Fu D-X, Ford E, van Zijl PCM, Zhou J
JournalInternational journal of radiation oncology, biology, physics
Volume83
Issue3
Paginatione431-6
Date Published2012 Jul 1
Abstract

Radiation necrosis is a major complication of radiation therapy. We explore the features of radiation-induced brain necrosis in the rat, using multiple MRI approaches, including T(1), T(2), apparent diffusion constant (ADC), cerebral blood flow (CBF), magnetization transfer ratio (MTR), and amide proton transfer (APT) of endogenous mobile proteins and peptides.

DOI10.3174/ajnr.A3505
Alternate JournalInt. J. Radiat. Oncol. Biol. Phys.