Anti-angiogenic effect of KH902 on retinal neovascularization.

TitleAnti-angiogenic effect of KH902 on retinal neovascularization.
Publication TypeJournal Article
Year of Publication2013
AuthorsWang F, Bai Y, Yu W, Han N, Huang L, Zhao M, Zhou A, Zhao M, Li X
JournalGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie
Volume251
Issue9
Pagination2131-9
Date Published2013 Sep
Abstract

KH902 is a fusion protein derived from the extracellular domains of vascular endothelial growth factor (VEGF) receptors 1 and 2 and the Fc portion of immunoglobulin G1 (IgG1). Retinopathy of prematurity (ROP) is an eye disease that affects premature babies who have received intensive neonatal care, and the disorganization of retinal blood vessels may result in scarring and retinal detachment. This study was designed to examine the inhibitory effects of KH902 on mice with oxygen-induced retinopathy (OIR), one of the animal models of ROP.

DOI10.1371/journal.pone.0075620
Alternate JournalGraefes Arch. Clin. Exp. Ophthalmol.