Amino acids and mTOR mediate distinct metabolic checkpoints in mammalian G1 cell cycle.

TitleAmino acids and mTOR mediate distinct metabolic checkpoints in mammalian G1 cell cycle.
Publication TypeJournal Article
Year of Publication2013
AuthorsSaqcena M, Menon D, Patel D, Mukhopadhyay S, Chow V, Foster DA
JournalPloS one
Volume8
Issue8
Paginatione74157
Date Published2013
Abstract

In multicellular organisms, cell division is regulated by growth factors (GFs). In the absence of GFs, cells exit the cell cycle at a site in G1 referred to as the restriction point (R) and enter a state of quiescence known as G0. Additionally, nutrient availability impacts on G1 cell cycle progression. While there is a vast literature on G1 cell cycle progression, confusion remains - especially with regard to the temporal location of R relative to nutrient-mediated checkpoints. In this report, we have investigated the relationship between R and a series of metabolic cell cycle checkpoints that regulate passage into S-phase.

DOI10.1371/journal.pone.0074157
Alternate JournalPLoS ONE