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Amino acids and mTOR mediate distinct metabolic checkpoints in mammalian G1 cell cycle.
|Title||Amino acids and mTOR mediate distinct metabolic checkpoints in mammalian G1 cell cycle.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Saqcena M, Menon D, Patel D, Mukhopadhyay S, Chow V, Foster DA|
In multicellular organisms, cell division is regulated by growth factors (GFs). In the absence of GFs, cells exit the cell cycle at a site in G1 referred to as the restriction point (R) and enter a state of quiescence known as G0. Additionally, nutrient availability impacts on G1 cell cycle progression. While there is a vast literature on G1 cell cycle progression, confusion remains - especially with regard to the temporal location of R relative to nutrient-mediated checkpoints. In this report, we have investigated the relationship between R and a series of metabolic cell cycle checkpoints that regulate passage into S-phase.
|Alternate Journal||PLoS ONE|