Altered expression of miRNAs in a dihydrotestosterone-induced rat PCOS model.

TitleAltered expression of miRNAs in a dihydrotestosterone-induced rat PCOS model.
Publication TypeJournal Article
Year of Publication2013
AuthorsHossain MM, Cao M, Wang Q, Kim JY, Schellander K, Tesfaye D, Tsang BK
JournalJournal of ovarian research
Volume6
Issue1
Pagination36
Date Published2013
Abstract

The polycystic ovary syndrome (PCOS) is a complex and heterogeneous endocrine condition characterized by hyperandrogenism, hyperinsulinemia, insulin resistance and chronic anovulation. Regulation and interaction of a multitude of genes required for follicular development are found to be altered in PCOS. MicroRNAs (miRNAs) mediate posttranscriptional gene regulation by binding to the 3´ untranslated region of mRNAs to either inhibit or enhance translation. However, the extent and regulation of miRNA expression in PCOS is poorly understood and the current study is the first to describe altered expression of miRNAs in PCOS.

DOI10.1093/jxb/ert290
Alternate JournalJ Ovarian Res