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Altered expression of miRNAs in a dihydrotestosterone-induced rat PCOS model.
|Title||Altered expression of miRNAs in a dihydrotestosterone-induced rat PCOS model.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Hossain MM, Cao M, Wang Q, Kim JY, Schellander K, Tesfaye D, Tsang BK|
|Journal||Journal of ovarian research|
The polycystic ovary syndrome (PCOS) is a complex and heterogeneous endocrine condition characterized by hyperandrogenism, hyperinsulinemia, insulin resistance and chronic anovulation. Regulation and interaction of a multitude of genes required for follicular development are found to be altered in PCOS. MicroRNAs (miRNAs) mediate posttranscriptional gene regulation by binding to the 3´ untranslated region of mRNAs to either inhibit or enhance translation. However, the extent and regulation of miRNA expression in PCOS is poorly understood and the current study is the first to describe altered expression of miRNAs in PCOS.
|Alternate Journal||J Ovarian Res|