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Alpha II-spectrin breakdown products serve as novel markers of brain injury severity in a canine model of hypothermic circulatory arrest.
| Title | Alpha II-spectrin breakdown products serve as novel markers of brain injury severity in a canine model of hypothermic circulatory arrest. |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Weiss ES, Wang KKW, Allen JG, Blue ME, Nwakanma LU, Liu MC, Lange MS, Berrong J, Wilson MA, Gott VL, Troncoso JC, Hayes RL, Johnston MV, Baumgartner WA |
| Journal | The Annals of thoracic surgery |
| Volume | 88 |
| Issue | 2 |
| Pagination | 543-50 |
| Date Published | 2009 Aug |
| Abstract | The development of specific biomarkers to aid in the diagnosis and prognosis of neuronal injury is of paramount importance in cardiac surgery. Alpha II-spectrin is a structural protein abundant in neurons of the central nervous system and cleaved into signature fragments by proteases involved in necrotic and apoptotic cell death. We measured cerebrospinal fluid alpha II-spectrin breakdown products (alphaII-SBDPs) in a canine model of hypothermic circulatory arrest (HCA) and cardiopulmonary bypass. |
| DOI | 10.1007/s11832-009-0190-9 |
| Alternate Journal | Ann. Thorac. Surg. |
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