ALK amplification and protein expression predict inferior prognosis in neuroblastomas.

TitleALK amplification and protein expression predict inferior prognosis in neuroblastomas.
Publication TypeJournal Article
Year of Publication2013
AuthorsWang M, Zhou C, Sun Q, Cai R, Li Y, Wang D, Gong L
JournalExperimental and molecular pathology
Volume95
Issue2
Pagination124-30
Date Published2013 Oct
Abstract

ALK gene has been identified as a major neuroblastoma (NBL) predisposition gene. But ALK gene copy number and protein expression in ganglioneuroblastoma (GNBL) and ganglioneuroma (GN) are poorly described in the literature. Furthermore, there are controversies on the correlation between ALK protein expression and clinical outcome in NBL.

DOI10.1080/10934529.2013.796820
Alternate JournalExp. Mol. Pathol.