Additive toxicity of β-amyloid by a novel bioactive peptide in vitro: possible implications for Alzheimer's disease.

TitleAdditive toxicity of β-amyloid by a novel bioactive peptide in vitro: possible implications for Alzheimer's disease.
Publication TypeJournal Article
Year of Publication2013
AuthorsGarcia-Ratés S, Lewis M, Worrall R, Greenfield S
JournalPloS one
Volume8
Issue2
Paginatione54864
Date Published2013
Abstract

β-amyloid is regarded as a significant factor in Alzheimer's disease: but inefficient therapies based on this rationale suggests that additional signalling molecules or intermediary mechanisms must be involved in the actual initiation of the characteristic degeneration of neurons. One clue could be that acetylcholinesterase, also present in amyloid plaques, is aberrant in peripheral tissues such as blood and adrenal medulla that can be implicated in Alzheimer's disease. The aim of this study was to assess the bioactivity of a fragment of acetylcholinesterase responsible for its non-enzymatic functions, a thirty amino acid peptide ("T30") which has homologies with β-amyloid.

DOI10.1371/journal.pone.0070185
Alternate JournalPLoS ONE