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β-Cyclodextrin conjugated magnetic, fluorescent silica core-shell nanoparticles for biomedical applications.
|Title||β-Cyclodextrin conjugated magnetic, fluorescent silica core-shell nanoparticles for biomedical applications.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Badruddoza AZM, Rahman MT, Ghosh S, Hossain MZ, Shi J, Hidajat K, Uddin MS|
|Date Published||2013 Jun 5|
We present synthesis of highly uniform magnetic nanocomposite material possessing an assortment of important functionalities: magnetism, luminescence, cell-targeting, and hydrophobic drug delivery. Magnetic particle Fe3O4 is encapsulated within a shell of SiO2 that ensures biocompatibility of the nanocomposite as well as act as a host for fluorescent dye (FITC), cancer-targeting ligand (folic acid), and a hydrophobic drug storage-delivering vehicle (β-cyclodextrin). Our preliminary results suggest that such core-shell nanocomposite can be a smart theranostic candidate for simultaneous fluorescence imaging, magnetic manipulation, cancer cell-targeting and hydrophobic drug delivery.
|Alternate Journal||Carbohydr Polym|