αB-crystallin negative astrocytic inclusions.

TitleαB-crystallin negative astrocytic inclusions.
Publication TypeJournal Article
Year of Publication2011
AuthorsBarnett BP, Bressler J, Chen T, Hutchins GM, Crain BJ, Kaufmann WE
JournalBrain & development
Volume33
Issue4
Pagination349-52
Date Published2011 Apr
Abstract

We report on an unusual pathological finding of astrocytes, observed in the brain of a 16-year-old African-American male with severe intellectual disability and spastic quadriplegia. The brain showed bilateral pericentral, perisylvian polymicrogyria and pachygyria, in conjunction with a large number of hypertrophic astrocytes with eosinophilic granular cytoplasmic inclusions. The astrocytic abnormality was more severe in the dysgenetic area but present throughout the cerebral cortex. Astrocytic inclusions stained with acid fuchsin, azocarmine and Holzer's stain, and were immunoreactive for GFAP, S-100, and ubiquitin, but not for αB-crystallin, filamin, vimentin, nestin, tau or α-synuclein. Based on the case and a review of the literature, the authors postulate that these astrocytic inclusions in the cerebral cortex reflect abnormalities in radial glial developmental processes, such as migration, differentiation, or glial-neuronal interaction function during neuronal migration.

DOI10.1097/BRS.0b013e3181e03881
Alternate JournalBrain Dev.