| Guanshu Liu, Ph.D. Research Scientist, Kennedy Krieger Institute Guanshu Liu is a research associate in F.M. Kirby Center at Kennedy Krieger Institute. He is also holding a jointing appointment as research associate in Russell H. Morgan Department of Radiology at Johns Hopkins University. |
Biographical Sketch:
Dr. Guanshu Liu graduated in 2008 with a Ph.D. degree in Biomedical Engineering at Case Western Reserve University, majoring in exploring novel responsive Magnetic resonance imaging (MRI) contrast agents for probing molecular alternations in living system. Then he joined Dr. Peter van Zijl’s group in F.M. Kirby Center at Kennedy Krieger Institute as a Research Associate.
Research Summary:
Dr. Liu’s present research focuses on developing new probes for using MRI to diagnose and cure central nervous system diseases. In particular, efforts have been made to establish a nanotechnological platform for imaging anti-cancer drug delivery in small animal model. In addition, he is developing new methodologies for using MRI to label therapeutic stem cells and monitor the viability and function of them in vivo. The ultimate goal is to translate these technologies to clinic for helping to cure these diseases in central nervous system that currently have low survival rates.
Recent Publications/Presentations:
Liu G, Ali MD, Griswold M, Tkach J, Pagel MD. PARACEST MRI with improved temporal resolution. Magnetic Resonance in Medicine, 2009, 61, (2),399-408
Liu G, Li Y, Pagel MD. Design and characterization of new irreversible responsive PARACEST MRI contrast agent that detects nitric oxide. Magnetic Resonance in Medicine, 2007, 58, (6),1249-56.
Ma Y, Liu G, Du M, Stayton I. Recent developments in the determination of urinary cancer biomarkers by capillary electrophoresis. Electrophoresis 2004, 25, (10-11), 1473-84.
Liu G, Chen J, Ma Y. Simultaneous determination of catecholamines and polyamines in PC-12 cell extracts by micellar electrokinetic capillary chromatography with ultraviolet absorbance detection. J Chromatogr B Analyt Technol Biomed Life Sci 2004, 805, (2), 281-8.
Chen J, Huang YW, Liu G, Afrasiabi Z, Sinn E, Padhye S, Ma Y. The cytotoxicity and mechanisms of 1,2-naphthoquinone thiosemicarbazone and its metal derivatives against MCF-7 human breast cancer cells. Toxicol Appl Pharmacol 2004, 197, (1), 40-8.
Liu G, Chen J, Che P, Ma Y. Separation and quantitation of short-chain coenzyme A's in biological samples by capillary electrophoresis. Anal Chem 2003, 75, (1), 78-82.
Liu G, Yao S, Ni J, Zhao F, Meng X. “Research of radioprotection by (-)-epigallocatechin gallate”. Fushe Yanjiu Yu Fushe Gongyi Xuebao 2002, 20, (2), 87-92.
Liu G, Lu C, Yao S, Zhao F, Li Y, Meng X, Gao J, Cai J, Zhang L, Chen Z. Radiosensitization mechanism of riboflavin in vitro. Science in China, Series C: Life Sciences 2002, 45, (4), 344-351.
Lu C, Liu G, Han Z, Tang H, Yao S, Lin N, Chen J, Mao Y. “Direct Evidence for Electron Transfer from Linoleic Acid to Triplet States of Riboflavin and FAD- A Laser Photolysis Study”, Chinese Journal of Organic Chemistry, 2001, 59(11), 1858-1863
Lu C, Han Z, Liu G, Cai X, Chen Y, Yao S. “Photophysical and photochemical processes of riboflavin (vitamin B2) by means of the transient absorption spectra in aqueous solution”. Science in China, Series B: Chemistry 2001, 44, (1), 39-48.
Liu G, Li Y, Pagel MD. Design and characterization of new irreversible responsive PARACEST MRI contrast agent that detects nitric oxide. Magnetic Resonance in Medicine, 2007, 58, (6),1249-56.
Ma Y, Liu G, Du M, Stayton I. Recent developments in the determination of urinary cancer biomarkers by capillary electrophoresis. Electrophoresis 2004, 25, (10-11), 1473-84.
Liu G, Chen J, Ma Y. Simultaneous determination of catecholamines and polyamines in PC-12 cell extracts by micellar electrokinetic capillary chromatography with ultraviolet absorbance detection. J Chromatogr B Analyt Technol Biomed Life Sci 2004, 805, (2), 281-8.
Chen J, Huang YW, Liu G, Afrasiabi Z, Sinn E, Padhye S, Ma Y. The cytotoxicity and mechanisms of 1,2-naphthoquinone thiosemicarbazone and its metal derivatives against MCF-7 human breast cancer cells. Toxicol Appl Pharmacol 2004, 197, (1), 40-8.
Liu G, Chen J, Che P, Ma Y. Separation and quantitation of short-chain coenzyme A's in biological samples by capillary electrophoresis. Anal Chem 2003, 75, (1), 78-82.
Liu G, Yao S, Ni J, Zhao F, Meng X. “Research of radioprotection by (-)-epigallocatechin gallate”. Fushe Yanjiu Yu Fushe Gongyi Xuebao 2002, 20, (2), 87-92.
Liu G, Lu C, Yao S, Zhao F, Li Y, Meng X, Gao J, Cai J, Zhang L, Chen Z. Radiosensitization mechanism of riboflavin in vitro. Science in China, Series C: Life Sciences 2002, 45, (4), 344-351.
Lu C, Liu G, Han Z, Tang H, Yao S, Lin N, Chen J, Mao Y. “Direct Evidence for Electron Transfer from Linoleic Acid to Triplet States of Riboflavin and FAD- A Laser Photolysis Study”, Chinese Journal of Organic Chemistry, 2001, 59(11), 1858-1863
Lu C, Han Z, Liu G, Cai X, Chen Y, Yao S. “Photophysical and photochemical processes of riboflavin (vitamin B2) by means of the transient absorption spectra in aqueous solution”. Science in China, Series B: Chemistry 2001, 44, (1), 39-48.
Contact Information:
Guanshu Liu, Ph.D.
F.M. Kirby Research Center
Kennedy Krieger Institute
707 N. Broadway, Baltimore MD 21205
(map & directions)
Telehone: (443) 287-8306
Facsimile: (443) 923-9505
Email: guanshu@mri.jhu.edu
F.M. Kirby Research Center
Kennedy Krieger Institute
707 N. Broadway, Baltimore MD 21205
(map & directions)
Telehone: (443) 287-8306
Facsimile: (443) 923-9505
Email: guanshu@mri.jhu.edu