She is the director of the Hunter Nelson Sturge-Weber Center at Kennedy Krieger Institute. She graduated from SUNY Buffalo School of medicine and received her training in Pediatrics at the Children’s Hospital of Buffalo and her Child Neurology training at Johns Hopkins Medicine. Her clinical specialization is in the treatment of the neurological aspects of Sturge-Weber syndrome.

Her clinical research interests are focused on improving the early diagnosis and treatment of brain involvement in Sturge-Weber syndrome, in order to prevent ischemic brain injury in these infants and young children, and on studies to understand what causes Sturge-Weber syndrome. Her laboratory research work deals with the pathogenesis of Sturge-Weber syndrome and on developing better neuroprotective and neuroregenerative responses to brain injury resulting from impaired blood flow to the brain.

Hatfield LA, Crone NE, Kossoff EH, Pyzik PA, Lin DDM, Kelley TM, Comi AM. (2007). "Quantitative EEG asymmetry correlates with clinical severity in unilateral Sturge-Weber syndrome." Epilepsia 48(1), 191-195

Comi AM. (2007). "Sturge-Weber syndrome and epilepsy: an argument for aggressive seizure management in these patients." Expert Rev. Neurotherapeutics 7(8), 951-956.

Comi AM, Cho E, Mulholland J, Hooper A, Li Q, Qu Y, Gary D, McDonald J, Johnston MV. (2008). "Neural stem cells reduce brain injury after unilateral carotid ligation." Pediatric Neurol. 38(2), 86-92.

Kadam SD, Mulholland JD, McDonald JW, Comi AM. (2008) "Neurogenesis and neuronal commitment following ischemia in a new mouse model for neonatal stroke. Brain Research 1208, 35-45.

Traa BS, Mulholland JD, Kadam SD, Johnston MV, Comi AM. (2008). "Gabapentin Neuroprotection and Seizure Suppression in Immature Mouse Brain Ischemia." Pediatric Research 64(1), 81-5.

Comi AM, Bellamkonda S, Ferenc LM, Cohen BA, Germain-Lee. (2008). Central Hypothyroidism and Sturge-Weber Syndrome." J. Child Neurology. 39(1), 58-62.